pdgf receptor การใช้

• Lydon's program focused on a signaling protein known as the PDGF receptor, which is active in a wide variety of tumors.
• It has also been shown that fibroblast growth factor ( FGF ) activates a signaling pathway that positively regulates the PDGF receptors in oligodendrocyte progenitor cells.
• Gleevec is part of a class of drugs that target PDGF receptors on cells, which receive the errant cancer-causing messages that result in cancer.
• Amanchy R, Zhong J, Hong R, Kim JH, Gucek M, Molina H, Pandey A . Identification of c-Src tyrosine kinase substrates in PDGF receptor signaling pathway.
• The encoded protein is a single pass type I membrane protein and acts as the receptor for tyrosine kinase transmembrane receptor and member of the CSF1 / PDGF receptor family of tyrosine-protein kinases.
• Age related downregulation of the PDGF receptor on islet beta cells has been demonstrated to prevent islet beta cell proliferation in both animal and human cells and its re-expression triggered beta cell proliferation and corrected glucose regulation via insulin secretion.
• Unfortunately for Novartis, the patient population for gastrointestinal stromal tumor is about 2, 000 a year in the United States, even smaller than that for CML . But STI-571 inhibits a third protein kinase, the PDGF receptor that was the initial target of the drug development program and is active in many common cancers.